Computer Simulation of a Nitric Oxide-Releasing Catheter with a Novel Stable Convection-Diffusion Equation Solver and Automatic Quantification of Lung Ultrasound Comets by Machine Learning

Biological transport processes often involve a boundary acting as separation of flow, most commonly in transport involving blood-contacting medical devices. The separation of flow creates two different scenarios of mass transport across the interface. No flow exists within the medical device and diffusion governs mass transport; both convection and diffusion exist when flow is present. The added convection creates a large concentration gradient around the interface. Computer simulation of such cases prove to be difficult and require proper shock capturing methods for the solutions to be stable, which is typically lacking in commercial solvers. In this thesis, we propose a second-order accurate numerical method for solving the convection-diffusion equation by using a gradient-limited Godunov-type convective flux and the multi-point flux approximation (MPFA) L-Method for the diffusion flux. We applied our solver towards simulation of a nitric oxide-releasing intravascular catheter. Intravascular catheters are essential for long-term vascular access in both diagnosis and treatment. Use of catheters are associated with risks for infection and thrombosis. Because infection and thrombosis lead to impaired flow and potentiality life threatening systemic infections, this leads to increased morbidity and mortality, requiring catheters to be replaced among other treatments for these complications. Nitric oxide (NO) is a potent antimicrobial and antithrombotic agent produced by vascular endothelial cells. The production level in vivo is so low that the physiological effects can only be seen around the endothelial cells. The catheter can incorporate a NO source in two major ways: by impregnating the catheter with NO-releasing compounds such as S-nitroso-N-acetyl penicillamine (SNAP) or using electrochemical reactions to generate NO from nitrites. We applied our solver to both situations to guide the design of the catheter. Simulations revealed that dissolved NO inside the catheter is depleted after 12 minutes without resupplying, and electrochemical release of NO requires 10.5 minutes to reach steady state. Lung edema is often present in patients with end-stage renal disease due to reduced filtration functions of the kidney. These patients require regular dialysis sessions to manage their fluid status. The clinical gold standard to quantify lung edema is to use CT, which exposes patients to high amounts of radiation and is not cost efficient. Fluid management in such patients becomes very challenging without a clear guideline of fluid to be removed during dialysis sessions. Hypotension during dialysis can limit fluid removal, even in the setting of ongoing fluid overload or congestive heart failure. Accurate assessment of the pulmonary fluid status is needed, so that fluid overload and congestive heart failure can be detected, especially in the setting of hypotension, allowing dialysis to be altered to improve fluid removal. Recently, reverberations in ultrasound signals, referred to as ``lung comets'' have emerged as a potential quantitative way to measure lung edema. Increased presence of lung comets is associated with higher amounts of pulmonary edema, higher mortality, and more adverse cardiac events. However, the lung comets are often counted by hand by physicians with single frames in lung ultrasound and high subjectivity has been found to exist among the counting by physicians. We applied image processing and neural network techniques as an attempt to provide an objective and accurate measurement of the amount of lung comets present. Our quantitative results are significantly correlated with diastolic blood pressure and ejection fraction.PHDBiomedical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/163182/1/micw_1.pd

One stone, two birds: A lightweight multidimensional learned index with cardinality support

Innovative learning based structures have recently been proposed to tackle index and cardinality estimation tasks, specifically learned indexes and data driven cardinality estimators. These structures exhibit excellent performance in capturing data distribution, making them promising for integration into AI driven database kernels. However, accurate estimation for corner case queries requires a large number of network parameters, resulting in higher computing resources on expensive GPUs and more storage overhead. Additionally, the separate implementation for CE and learned index result in a redundancy waste by storage of single table distribution twice. These present challenges for designing AI driven database kernels. As in real database scenarios, a compact kernel is necessary to process queries within a limited storage and time budget. Directly integrating these two AI approaches would result in a heavy and complex kernel due to a large number of network parameters and repeated storage of data distribution parameters. Our proposed CardIndex structure effectively killed two birds with one stone. It is a fast multidim learned index that also serves as a lightweight cardinality estimator with parameters scaled at the KB level. Due to its special structure and small parameter size, it can obtain both CDF and PDF information for tuples with an incredibly low latency of 1 to 10 microseconds. For tasks with low selectivity estimation, we did not increase the model's parameters to obtain fine grained point density. Instead, we fully utilized our structure's characteristics and proposed a hybrid estimation algorithm in providing fast and exact results

Maintenance policy for two-stage deteriorating mode system based on cumulative damage model

For the system degradation process undergoing a sudden change, optimal maintenance policies were developed using the cumulative damage model and two-stage degradation modeling. Single shock damage value and the number of shock times are assumed to be normal distribution and homogeneous Poisson process, respectively. On this basis, average long-run cost rate of a renewal cycle was modeled with considering the probabilities of corrective, preventive and continuous monitoring, respectively. In order to develop an optimal policy, four types of maintenance policies (i.e., global, time-depended, adaptive and simplified adaptive policies) were analyzed with different alarm thresholds and inter-inspection time. Influence analysis of different parameters for maintenance policy was given, where different maintenance policies were compared in terms of average long-run cost rate. In addition, the impacts of degradation model parameters (i.e., change-point distribution, shock strength, shock frequency) on the average long-run cost rate were analyzed. Finally, maintenance policy for gearbox degradation experiment was analyzed in case study

Experimental study on adhesion of oxide scale on hot-rolled steel strip

An experimental method was developed to study the adherence properties of the oxide scale formed on microalloyed low carbon steel after hot strip rolling. The evolution of the oxide scale during laminar cooling was investigated using Gleeble 3500 Thermal-Mechanical Simulator connected with a humid air generator. After the sample cooled down to ambient temperature, the oxide scale was protected by lacquer to prevent the scale from losing. Physicochemical characteristics of the oxide scale were examined and the adherence mechanism was discussed. Decomposed wustite a mixture of α-iron and magnetite (Fe3O4), can substantially improve the integrity of oxide scale. However, large quantities of hematite (Fe2O3) or retained wustite (FeO) were found detrimental to the adhesion of the oxide scale. It is found that the adherence of oxide scales significantly depends on the phase composition of oxide scales with different thickness

Inspection period determination for two-stage degraded system

At present studies on degradation process are mainly single stage degradation mode, however, in practice the system degradation process is generally multi-stage. Based on general degradation process modeling, the paper assumed degenerate distribution of two-stage mode obey various normal distribution, shock times obey Poisson process. Reliability modeling and mean time to failure modeling of two-stage degraded mode are studied. Functional check period determination methods are used to calculate inspection periods for different degradation stage. In numerical example, inspection periods for system with two-stage degradation process are analyzed

Phonemic Adversarial Attack against Audio Recognition in Real World

Recently, adversarial attacks for audio recognition have attracted much attention. However, most of the existing studies mainly rely on the coarse-grain audio features at the instance level to generate adversarial noises, which leads to expensive generation time costs and weak universal attacking ability. Motivated by the observations that all audio speech consists of fundamental phonemes, this paper proposes a phonemic adversarial tack (PAT) paradigm, which attacks the fine-grain audio features at the phoneme level commonly shared across audio instances, to generate phonemic adversarial noises, enjoying the more general attacking ability with fast generation speed. Specifically, for accelerating the generation, a phoneme density balanced sampling strategy is introduced to sample quantity less but phonemic features abundant audio instances as the training data via estimating the phoneme density, which substantially alleviates the heavy dependency on the large training dataset. Moreover, for promoting universal attacking ability, the phonemic noise is optimized in an asynchronous way with a sliding window, which enhances the phoneme diversity and thus well captures the critical fundamental phonemic patterns. By conducting extensive experiments, we comprehensively investigate the proposed PAT framework and demonstrate that it outperforms the SOTA baselines by large margins (i.e., at least 11X speed up and 78% attacking ability improvement)

Classification-Aided Robust Multiple Target Tracking Using Neural Enhanced Message Passing

We address the challenge of tracking an unknown number of targets in strong clutter environments using measurements from a radar sensor. Leveraging the range-Doppler spectra information, we identify the measurement classes, which serve as additional information to enhance clutter rejection and data association, thus bolstering the robustness of target tracking. We first introduce a novel neural enhanced message passing approach, where the beliefs obtained by the unified message passing are fed into the neural network as additional information. The output beliefs are then utilized to refine the original beliefs. Then, we propose a classification-aided robust multiple target tracking algorithm, employing the neural enhanced message passing technique. This algorithm is comprised of three modules: a message-passing module, a neural network module, and a Dempster-Shafer module. The message-passing module is used to represent the statistical model by the factor graph and infers target kinematic states, visibility states, and data associations based on the spatial measurement information. The neural network module is employed to extract features from range-Doppler spectra and derive beliefs on whether a measurement is target-generated or clutter-generated. The Dempster-Shafer module is used to fuse the beliefs obtained from both the factor graph and the neural network. As a result, our proposed algorithm adopts a model-and-data-driven framework, effectively enhancing clutter suppression and data association, leading to significant improvements in multiple target tracking performance. We validate the effectiveness of our approach using both simulated and real data scenarios, demonstrating its capability to handle challenging tracking scenarios in practical radar applications.Comment: 15 page